Hundreds dead as Israel-Iran conflict escalates

The intensifying conflict between Israel and Iran entered its third day Sunday, with deadly strikes exchanged across both countries and no signs of de-escalation. Air raids and missile attacks have left hundreds dead and wounded on both sides, as fears mount that the confrontation could spiral into a broader regional war.

Israel launched a new wave of airstrikes on Sunday, targeting Iran’s nuclear and military infrastructure, including a defense ministry site and key missile facilities. Explosions rocked Iran’s capital, Tehran, throughout the day, and emergency shelters were opened in metro stations and mosques as residents braced for further attacks. In response, Iran fired over 270 missiles into Israeli territory, with at least 22 penetrating the country’s air defense systems.

Iranian and international observers have reported severe damage to critical energy facilities, including an oil refinery near Tehran and a gas processing plant at the South Pars field. Satellite imagery reviewed by experts has confirmed significant destruction at Iran’s main nuclear enrichment facility in Natanz, as well as damage to four buildings at the Isfahan uranium-conversion site.

Human rights monitors estimate that at least 406 people have been killed in Iran since the strikes began on Friday, including civilians, military personnel, and scientific staff. More than 650 others have been wounded. Iran has not released official casualty figures. In Israel, 14 people have been confirmed dead, including children, with hundreds more injured across several cities, including Bat Yam, Tamra, and Rehovot.

Among the Israeli targets hit was the Weizmann Institute of Science, a major research center, although no casualties were reported there. A missile strike in the city of Haifa damaged an oil refinery but caused no injuries.

Efforts to restart diplomatic engagement collapsed over the weekend. Planned negotiations on Iran’s nuclear program were abruptly canceled, with Tehran calling the talks unjustifiable in light of the military escalation. U.S. officials indicated a willingness to resume dialogue but said prospects were dim unless the conflict subsides.

The economic impact of the strikes is beginning to ripple across the region. Israel’s main international airport and airspace remain closed, and analysts are warning of potential disruptions to global energy markets if attacks on Iranian oil infrastructure continue.

Israeli leadership has warned of expanded operations if Iranian aggression persists, while Iran has signaled its readiness to intensify retaliatory strikes. Regional governments and global powers are urging restraint but have so far failed to influence either side’s strategic decisions.